Agonodepsides a and B: two new depsides from a filamentous fungus F7524

J Nat Prod. 2002 Jul;65(7):1037-8. doi: 10.1021/np010626i.

Abstract

Two new compounds, agonodepsides A (1) and B (2), were isolated from a nonsporulating filamentous fungus, F7524. The compounds were purified via reversed-phase chromatography and their structures determined by spectroscopic methods. Agonodepside A (1) was found to inhibit the mycobacterial InhA enzyme with an IC50 value of 75 microM, while 2 was inactive at 100 microM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Proteins
  • Depsides
  • Derris / chemistry
  • Fungi / chemistry*
  • Hydroxybenzoates / chemistry
  • Hydroxybenzoates / isolation & purification*
  • Hydroxybenzoates / pharmacology
  • Inhibitory Concentration 50
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Mycobacterium tuberculosis / drug effects
  • Mycobacterium tuberculosis / enzymology
  • NAD / drug effects
  • Nuclear Magnetic Resonance, Biomolecular
  • Oxidoreductases / drug effects
  • Plant Leaves / chemistry
  • Plants / chemistry

Substances

  • Bacterial Proteins
  • Depsides
  • Hydroxybenzoates
  • agonodepside A
  • agonodepside B
  • NAD
  • Oxidoreductases
  • InhA protein, Mycobacterium